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The Veterinary Record, Vol 109, Issue 4, 75-76
Copyright © 1981 by British Veterinary Association

Papers & Articles

Elevation of blood keto acids in cerebrocortical necrosis

EE Edwin and R Jackman

Values of various alpha-keto acids in whole blood were determined from cases of cerebrocortical necrosis (CCN), a thiamine deficiency disease, and were compared with those from normal animals. Thiamine pyrophosphate is an essential cofactor in the decarboxylation of many alpha-keto acids and this was reflected in elevated values not only of pyruvic acid but of glyoxylic, alpha-keto glutaric, phenyl pyruvic and hydroxyphenyl pyruvic acids in the CCN cases.




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Copyright © 1981 British Veterinary Association