The Veterinary Record
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The Veterinary Record, Vol 115, Issue 23, 599-600
Copyright © 1984 by British Veterinary Association

Papers & Articles

Effect of feeding on the fate of orally administered phenylbutazone, trimethoprim and sulphadiazine in the horse

JA Bogan, A Galbraith, P Baxter, NM Ali, and SE Marriner

Phenylbutazone, sulphadiazine and trimethoprim were administered to three horses on two occasions, recently fed and unfed, and the effect of feeding on the pharmacokinetics of the three drugs assessed. The mean peak concentrations of phenylbutazone and trimethoprim were reduced by feeding by 34 and 75 per cent, respectively. The pharmacokinetics of sulphadiazine were not significantly affected.




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Copyright © 1984 British Veterinary Association