Salinomycin poisoning in horses

School of Veterinary Science, University of Bristol.

Six cases of accidental salinomycin poisoning in horses are described. The horses were fed a contaminated ration and presented clinical signs which were extremely varied in nature and severity. However, the range of signs, including anorexia, colic, weakness and ataxia bore similarities to those described in horses poisoned with the related ionophore monensin. Other similarities became apparent in serum biochemical profiles of the clinical cases. Although ionophore toxicity is rarely reported in horses they appear to be particularly susceptible, and it should therefore be considered as a differential diagnosis of digestive upsets or locomotory disorders at establishments where ionophore-treated feeds are used therapeutically in other species.

This article has been cited by other articles:

				J. S. Lagas, R. W. Sparidans, R. A. B. van Waterschoot, E. Wagenaar, J. H. Beijnen, and A. H. Schinkel P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin Antimicrob. Agents Chemother., March 1, 2008; 52(3): 1034 - 1039. [Abstract] [Full Text] [PDF]