An alternative protocol for the medical management of canine pituitary-dependent hyperadrenocorticism

Small Animal Clinic, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.

As an alternative to the o,p'-DDD treatment aimed at the selective destruction of the adrenal cortices, the authors have introduced a protocol aimed at the complete destruction of the adrenal cortices. It consists of a longer period of daily treatment with o,p'-DDD and lifelong substitution for primary hypoadrenocorticism. The results obtained in 41 dogs, with a minimum follow-up period of one year, indicate that this approach has advantages over lifelong maintenance therapy with o,p'-DDD.

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				M. Clemente, P. J. De Andres, C. Arenas, C. Melian, M. Morales, and M. D. Perez-Alenza Comparison of non-selective adrenocorticolysis with mitotane or trilostane for the treatment of dogs with pituitary-dependent hyperadrenocorticism Vet Rec., December 15, 2007; 161(24): 805 - 809. [Abstract] [Full Text] [PDF]