Bovine endometritis: comparative efficacy of alfaprostol and intrauterine therapies, and other factors influencing clinical success

Department of Veterinary Clinical Science, University of Liverpool Veterinary Field Station, Neston, Wirral, Merseyside.

A comparative study of the treatment of 306 severe, moderate, or mild cases of bovine endometritis was carried out over two calving seasons. The cases were treated with alfaprostol, or an intrauterine antibacterial preparation, or with a combination of both therapies. There was no significant difference between the efficacies of these treatments, and a single injection of alfaprostol was effective in 74 per cent of the cases treated. The effectiveness of the treatments was related to the degree of self-cure of the endometritis after parturition, the luteal activity at the time of treatment, and farm management factors affecting the health and condition of the calving cows.

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				S. J. LeBlanc, T. F. Duffield, K. E. Leslie, K. G. Bateman, G. P. Keefe, J. S. Walton, and W. H. Johnson The Effect of Treatment of Clinical Endometritis on Reproductive Performance in Dairy Cows J Dairy Sci, September 1, 2002; 85(9): 2237 - 2249. [Abstract] [Full Text] [PDF]