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The Veterinary Record, Vol 138, Issue 11, 253-256
Copyright © 1996 by British Veterinary Association

Side effects of oral antimicrobial agents in the horse: a comparison of pivampicillin and trimethoprim/sulphadiazine

J. M. Ensink DVM, PhD1, W. R. Klein DVM, PhD1, A. Barneveld DVM, PhD1, A. S. J. P. A. M. van Miert DVM, PhD2, and A. G. Vulto MPharm, PhD3

1 Department of General and Large Animal Surgery, Utrecht University, PO Box 80.153, 3508 td Utrecht, The Netherlands
2 Department of Veterinary Basic Sciences, Division of Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.153, 3508 td Utrecht, The Netherlands
3 Veterinary Hospital Pharmacy, Utrecht University, PO Box 80.153, 3508 td Utrecht, The Netherlands

To evaluate the side effects of oral pivampicillin and trimetho-prim/sulphadiazine, 200 horses receiving these antimicrobial agents were studied. The horses received either trimethoprim/sulphadiazine (30 mg/kg twice daily) or pivampicillin (25 mg/kg twice daily) for three or more days. No adverse effects other than loose faeces and diarrhoea were detected. The risk of diarrhoea was significantly less after the oral administration of pivampicillin (3 per cent) than after trimethoprim/sulphadiazine (7 per cent). Horses whose appetite was reduced appeared to be predisposed to develop diarrhoea after the administration of either oral antimicrobial agent.






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Copyright © 1996 British Veterinary Association