| HOME | CURRENT ISSUE | TABLE OF CONTENTS | ARCHIVE | SEARCH | SUBSCRIPTIONS | JOBS | FEEDBACK | HELP |
|
|
|
|||||||||
|
|||||||||||
The Veterinary Record, Vol 149, Issue 15, 443-449
Copyright © 2001 by British Veterinary Association
1 Veterinary Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA
2 Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX
3 Department of Veterinary Clinical Science and Animal Husbandry, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX
4 Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Box 7019, SE-750 07 Uppsala, Sweden
Nine cows which were naturally and persistently infected with Neospora caninum were housed and observed intensively throughout pregnancy. No recrudescence of a latent infection was detected by PCR tests on maternal blood but fetal infection, implying a recrudescence of maternal parasitosis, was associated with a marked increase in maternal antibody. The increase occurred in the second half of pregnancy in five cows which infected their calves, and before mid-pregnancy in one cow which aborted. There was no change in the avidity of the antibody, which remained high and characteristic of long-term infection. In three infected cows that gave birth to uninfected calves there was no marked increase in maternal antibody. Antigen-specific interferon 
responses of peripheral blood mononuclear cells were observed in all the infected cattle but they did not vary significantly either during pregnancy, or whether the cows did or did not infect their calves, although the responses were consistently higher in the latter. There was no change in the plasma concentrations of cortisol or acute phase proteins associated with the recrudescence of the parasite. Three uninfected cows housed with the infected cows remained uninfected throughout the experiment. No immunosuppressive event was detected which might have provoked parasite recrudescence but the acute antibody rise associated with transplacental infection provides a valuable, non-invasive marker for further studies to investigate the cause and consequences of parasite recrudescence in N caninum infection in cattle.
This article has been cited by other articles:
|
|
 |
|
  P. Huang, M. Liao, H. Zhang, E.-g. Lee, Y. Nishikawa, and X. Xuan Dense-Granule Protein NcGRA7, a New Marker for the Serodiagnosis of Neospora caninum Infection in Aborting Cows Clin. Vaccine Immunol., December 1, 2007; 14(12): 1640 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Dubey, G. Schares, and L. M. Ortega-Mora Epidemiology and Control of Neosporosis and Neospora caninum Clin. Microbiol. Rev., April 1, 2007; 20(2): 323 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. L. Williams, C. S. Guy, R. F. Smith, J. Ellis, C. Bjorkman, M. P. Reichel, and A. J. Trees Immunization of Cattle with Live Tachyzoites of Neospora caninum Confers Protection against Fetal Death Infect. Immun., March 1, 2007; 75(3): 1343 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Staska, T. C. McGuire, C. J. Davies, H. A. Lewin, and T. V. Baszler Neospora caninum-Infected Cattle Develop Parasite-Specific CD4+ Cytotoxic T Lymphocytes Infect. Immun., June 1, 2003; 71(6): 3272 - 3279. [Abstract] [Full Text] [PDF]
|
|
| HOME | CURRENT ISSUE | TABLE OF CONTENTS | ARCHIVE | SEARCH | SUBSCRIPTIONS | JOBS | FEEDBACK | HELP |
