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Papers and Articles |
1 Department of Veterinary Diagnostic and Production Animal Medicine, College of
Veterinary Medicine, Iowa State University, Ames, IA 50011,
USA
2 Department of Veterinary Microbiology and Preventive Medicine, College of
Veterinary Medicine, Iowa State University, Ames, IA 50011,
USA
3 Department of Biomedical Sciences and Pathobiology, Center of Molecular
Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia
Polytechnic Institute and State University, Blacksburg, VA
24061-03542, USA
To determine whether there is an effect of the timing of vaccination on porcine circovirus type 2 (PCV-2) replication and PCV-2-associated lesions, 78 pigs were randomly assigned to eight groups: group 1 (10 pigs) was vaccinated with a commercial Mycoplasma hyopneumoniae vaccine at two and four weeks of age, group 2 (nine pigs) was vaccinated at four and six weeks of age, group 3 (10 pigs) at six and eight weeks of age and group 4 (10 pigs) at eight and 10 weeks of age; group 5 (nine pigs) was vaccinated once with a double dose at four weeks of age, and group 6 (10 pigs) was vaccinated once with a double dose at eight weeks of age. Groups 7 and 8, both of 10 pigs, were not vaccinated. At eight weeks of age, the pigs in groups 1 to 7 were inoculated with PCV-2. Fourteen days after they had been inoculated, the pigs in groups 1, 4 and 5 had significantly (P<0·05) more copies of the PCV-2 genome in their serum than the unvaccinated pigs. Microscopically, 14 of the 68 inoculated pigs had normal lymphoid tissues, 40 had mild PCV-2-associated lymphoid lesions and 14 had moderate lesions. The mean overall lymphoid lesions (lymphoid depletion, granulomatous inflammation, and quantity of PCV-2 antigen in spleen, tonsil, and five lymph nodes) were significantly (P<0·05) more severe in groups 4 and 5 than in groups 2, 3, 7 and 8.
This article has been cited by other articles:
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  T. Opriessnig, S. Ramamoorthy, D. M. Madson, A. R. Patterson, N. Pal, S. Carman, X. J. Meng, and P. G. Halbur Differences in virulence among porcine circovirus type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection J. Gen. Virol., October 1, 2008; 89(10): 2482 - 2491. [Abstract] [Full Text] [PDF]
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 T. Opriessnig, X.-J. Meng, and P. G. Halbur Porcine Circovirus Type 2 associated disease: Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies J Vet Diagn Invest, November 1, 2007; 19(6): 591 - 615. [Abstract] [Full Text] [PDF]
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T. Opriessnig, N. E. McKeown, E.-M. Zhou, X.-J. Meng, and P. G. Halbur Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-associated lesions provides evidence for differences in virulence. J. Gen. Virol., October 1, 2006; 87(Pt 10): 2923 - 2932. [Abstract] [Full Text] [PDF]
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 T. Opriessnig, N. E. McKeown, K. L. Harmon, X. J. Meng, and P. G. Halbur Porcine circovirus type 2 infection decreases the efficacy of a modified live porcine reproductive and respiratory syndrome virus vaccine. Clin. Vaccine Immunol., August 1, 2006; 13(8): 923 - 929. [Abstract] [Full Text] [PDF]
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 T. Opriessnig, M. Fenaux, P. Thomas, M. J. Hoogland, M. F. Rothschild, X. J. Meng, and P. G. Halbur Evidence of Breed-dependent Differences in Susceptibility to Porcine Circovirus Type-2-associated Disease and Lesions Vet. Pathol., May 1, 2006; 43(3): 281 - 293. [Abstract] [Full Text] [PDF]
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