The Veterinary Record 159:552-557 (2006)
© 2006 British Veterinary Association
Clinical and anti-inflammatory effects of treating endotoxin-challenged pigs with meloxicam
G. M. Friton, DrMedVet1,
H. Schmidt, DrMedVet2 and
W. Schrödl, DrMedVet3
1 Boehringer Ingelheim Animal Health, Binger Strasse 173, D-55216 Ingelheim am
Rhein, Germany
2 Harlan Bioservice for Science, Sudkampen 31, D-29664 Walsrode, Germany
3 Institute for Bacteriology and Mycology, Faculty of Veterinary Medicine,
University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany
The clinical and anti-inflammatory effects of a single treatment of
0·4 mg meloxicam/kg bodyweight on pigs that had been challenged with
Escherichia coli endotoxin were investigated. Significantly lower
total clinical scores were recorded in pigs treated with meloxicam than in
pigs treated with a placebo. Significantly higher mean serum concentrations of
thromboxane B2 were also recorded in pigs treated with a placebo
for up to 24 hours after the challenge. The serum concentrations of acute
phase proteins and specific antibody titres to E coli
lipopolysaccharide were unaffected by the meloxicam. The meloxicam treatment
was well tolerated.
Copyright © 2006 British Veterinary Association
