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Plasma concentrations of voriconazole in falcons

¹ Clinic for Birds and Reptiles, University of Leipzig, An den Tierkliniken 15, D-04103 Leipzig, Germany
² Institute for Pharmacology and Toxicology, University of Leipzig, An den Tierkliniken 15, D-04103 Leipzig, Germany
³ Dubai Falcon Hospital, PO Box 23919 Dubai, United Arab Emirates

Doses of 12·5 mg voriconazole/kg bodyweight administered every 12 hours by crop gavage to six falcons for 14 days provided peak plasma concentrations of more than 1 µg/ml, but the trough concentrations were lower and sometimes undetectable. Administering the same doses incorporated into meat that was fed to one falcon for seven days and to three falcons for up to 91 days provided similar plasma concentrations.