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The Veterinary Record 162:509-513 (2008)
© 2008 British Veterinary Association

Papers and Articles

E-cadherin expression in canine cutaneous histiocytomas

S. J. Baines, MA, VetMB, PhD, CertVR, CertSAS, DipECVS, MRCVS1,2, E. F. McInnes, BVSc, MRCPath, PhD, MRCVS1 and I. McConnell, BVM&S, MA, PhD, FRCPath, FRSE, MRCVS1

1 Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES
2 Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA

Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.




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I. PIRES, F. L. QUEIROGA, A. ALVES, F. SILVA, and C. LOPES
Decrease of E-Cadherin Expression in Canine Cutaneous Histiocytoma Appears to be Related to its Spontaneous Regression
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[Abstract] [Full Text] [PDF]

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 Vet Rec.Home page
I. Pires, A. Alves, P. Rodrigues, F. L. Queiroga, and C. S. Lopes
E-cadherin expression in canine cutaneous histiocytoma
Vet Rec., July 12, 2008; 163(2): 59 - 60.
[Full Text] [PDF]


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