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Analysis of cerebrospinal fluid in healthy rabbits and rabbits with clinically suspected encephalitozoonosis

¹ Clinic of Small Animal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilian University Munich, Veterinaerstrasse 13, 80539 Munich, Germany
² Department of General Pathology and Neuropathology, Faculty of Veterinary Medicine, Ludwig Maximilian University Munich, Veterinaerstrasse 13, 80539 Munich, Germany
³ Centre of Preclinical Research, Ismaningerstrasse 22, 81675 Munich, Germany
⁴ Institute for Statistics, Ludwig Maximilian University Munich, Ludwigstrasse 33, 80539 Munich, Germany

Correspondence: Correspondence to Dr Fischer

Samples of uncontaminated cerebrospinal fluid (CSF) were collected from the cisterna magna of 20 healthy laboratory rabbits and 21 pet rabbits with vestibular disease and/or paresis due to clinically suspected encephalitozoonosis. In the healthy rabbits' CSF the leucocyte count was 4 leucocytes/µl (median 1·5 µl) and the concentration of protein ranged from 0·13 to 0·31 g/l (median 0·24 g/l). In the diseased rabbits, the number of leucocytes ranged from 1 to 87/µl (median 15/µl; P<0·001), and the concentration of protein ranged from 0·31 to 1·54 g/l (median 0·79 g/l; P<0·001); a cytological evaluation showed that they had greater numbers of lymphocytes and monocytes. It was concluded that encephalitozoonosis in rabbits is characterised by lymphomonocytic pleocytosis in CSF.