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Responses of pigs to a re-challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure

¹ National Veterinary Institute, Department of Animal Health and Antimicrobial Strategies, SE-751 89 Uppsala, Sweden
² Departamento de Sanidad Animal, Unidad de Microbiología e Immunología, Facultad de Veterinaria, Universidad de León, 24007, León, Spain
³ Swedish University of Agricultural Sciences, Department of Biomedicine and Veterinary Public Health, Section of Immunology, PO Box 588, Biomedical Centre, SE-751 23 Uppsala, Sweden

Correspondence: E-mail for correspondence: marie.sjolund{at}sva.se

Four groups of six specific pathogen-free (SPF) pigs were inoculated intranasally with Actinobacillus pleuropneumoniae serotype 2 and treated with either enrofloxacin, tetracycline or penicillin at the onset of clinical disease, or left untreated. A fifth group was left uninoculated. The inoculated control and the penicillin-treated groups developed severe disease, but the groups treated with enrofloxacin and tetracycline recovered rapidly. All the inoculated pigs, except those treated with enrofloxacin developed serum antibodies to A pleuropneumoniae. On day 28, all five groups were challenged with A pleuropneumoniae without any subsequent treatment. The previously uninoculated control group and the enrofloxacin-treated group developed severe disease, but the three seropositive groups remained unaffected.