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Pharmacokinetics and efficacy of teicoplanin against intramammary infections in sheep

¹ Department of Pharmacobiology, Polo Universitario SS Annunziata, University of Messina, Italy
² Department of Veterinary Public Health, Polo Universitario SS Annunziata, University of Messina, Italy
³ Department of Veterinary Sciences and Technologies for Food Safety, University of Milan, Via Celoria 10, Milan, Italy

Correspondence: Correspondence to Dr Cagnardi, e-mail: petra.cagnardi{at}unimi.it

The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 [0·24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9·23 [0·74] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactiae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.

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